Inflammation, Haemostatic Disturbance, and Obesity : Possible Link to Pathogenesis of Diabetic Retinopathy in Type 2 Diabetes
Joint Authors
Jazbec, Anamarija
Ljubić, Spomenka
Gverović Antunica, Antonela
Poljičanin, Tamara
Tomić, Martina
Kaštelan, Snježana
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
The pathogenesis of diabetic retinopathy (DR) is insufficiently understood but may possibly involve chronic, low-grade inflammation.
The aim of this cross-sectional study was to investigate the relationship between inflammatory and haemostatic markers, other markers of endothelial dysfunction and anthropometric parameters, and their association with DR in patients with type 2 diabetes.
Methods.
According to the DR status patients were divided into three groups: no retinopathy, mild/moderate nonproliferative (NPDR), and severe NPDR/proliferative retinopathy (PDR).
Results.
The groups did not differ in the levels of inflammatory and haemostatic markers, other markers of endothelial dysfunction, and anthropometric parameters.
After dividing the patients according to the level of obesity (defined by BMI, WC, and WHR) into three groups ANOVA showed the differences in C-reactive protein according to the WC (P=0.0265) and in fibrinogen according to the WHR (P=0.0102) as well as in total cholesterol (P=0.0109) and triglycerides (P=0.0133) according to the BMI.
Logistic regression analyses showed that diabetes duration and prolonged poor glycemic control are the main predictors of retinopathy in patients with type 2 diabetes.
Conclusion.
Interrelations between obesity, inflammation, haemostatic disturbance, and other risk factors may possibly play an important additional role in endothelial dysfunction involved in the pathogenesis of diabetic retinopathy.
American Psychological Association (APA)
Tomić, Martina& Ljubić, Spomenka& Kaštelan, Snježana& Gverović Antunica, Antonela& Jazbec, Anamarija& Poljičanin, Tamara. 2013. Inflammation, Haemostatic Disturbance, and Obesity : Possible Link to Pathogenesis of Diabetic Retinopathy in Type 2 Diabetes. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-500594
Modern Language Association (MLA)
Tomić, Martina…[et al.]. Inflammation, Haemostatic Disturbance, and Obesity : Possible Link to Pathogenesis of Diabetic Retinopathy in Type 2 Diabetes. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-500594
American Medical Association (AMA)
Tomić, Martina& Ljubić, Spomenka& Kaštelan, Snježana& Gverović Antunica, Antonela& Jazbec, Anamarija& Poljičanin, Tamara. Inflammation, Haemostatic Disturbance, and Obesity : Possible Link to Pathogenesis of Diabetic Retinopathy in Type 2 Diabetes. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-500594
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500594