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The Molecular Pathogenesis and Clinical Implications of Hepatocellular Carcinoma
Joint Authors
Hirata, Koichi
Mizuguchi, Toru
Kawamoto, Masaki
Meguro, Makoto
Source
International Journal of Hepatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The prognosis of hepatocellular carcinoma (HCC) is affected by tumoral factors and liver functions; therefore it is often difficult to select the appropriate therapeutic methods for HCC.
Recently, two global phase III trials showed that sorafenib, which is a tyrosine kinase inhibitor, improved the prognosis of patients with advanced HCC.
As a new therapeutic strategy for HCC, sorafenib is expected to expand the indication for HCC in the future.
However, it alone is insufficient for the molecular-targeted treatment of HCC because the signaling pathway exists not only in cancer cells but also in normal cells.
Recently, cancer stem cells (CSCs) have attracted attention as a novel therapeutic target for HCC.
There is now much evidence that stem cell properties such as self-renewal, unlimited proliferation, and differentiation are highly relevant to cancer recurrence and the drug resistance of HCC.
In this review, we describe the molecular pathogenesis and the current state and future development of molecular- and CSC-therapeutic targeted agents for HCC, citing various reports.
American Psychological Association (APA)
Meguro, Makoto& Mizuguchi, Toru& Kawamoto, Masaki& Hirata, Koichi. 2011. The Molecular Pathogenesis and Clinical Implications of Hepatocellular Carcinoma. International Journal of Hepatology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-500595
Modern Language Association (MLA)
Meguro, Makoto…[et al.]. The Molecular Pathogenesis and Clinical Implications of Hepatocellular Carcinoma. International Journal of Hepatology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-500595
American Medical Association (AMA)
Meguro, Makoto& Mizuguchi, Toru& Kawamoto, Masaki& Hirata, Koichi. The Molecular Pathogenesis and Clinical Implications of Hepatocellular Carcinoma. International Journal of Hepatology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-500595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500595