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Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles
Joint Authors
Akbar, Erum
Usman, Muhammad
Yaqub, Ghazala
Iqbal, Mehwish
Hannan, Abdul
Sadiq, Zubi
Hamid, Almas
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Strategy to synthesize novel carbazole, that is, 2,3-dihydro-2-phenyl-6H-pyridazino[4, 5-b]carbazole-1,4-dione (2), is developed as key reaction.
This novel compound showed ideal reactivity toward different functional groups like methyl, carboxylic, nitro, piperazine, and amine; thus series of its derivatives are synthesized sequentially with the aim to fuel up the carbazole compounds with new versatile derivatives.
All compounds were investigated for their activity against bacteria (MRSA and S.
typhi) and fungi (Candida albicans).
Among tested compounds 3, 6, and 8 exhibited pronounced antibacterial activities while 2, 5, and 9 also showed moderate activities.
2, 3, 5, 7, and 9 showed stronger antifungal activity against Candida albicans comparable to positive control.
American Psychological Association (APA)
Yaqub, Ghazala& Hannan, Abdul& Akbar, Erum& Usman, Muhammad& Hamid, Almas& Sadiq, Zubi…[et al.]. 2012. Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-500606
Modern Language Association (MLA)
Yaqub, Ghazala…[et al.]. Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles. Journal of Chemistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-500606
American Medical Association (AMA)
Yaqub, Ghazala& Hannan, Abdul& Akbar, Erum& Usman, Muhammad& Hamid, Almas& Sadiq, Zubi…[et al.]. Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-500606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500606