The Influence of Phosphate Buffer on the Formation of N-Nitrosodimethylamine from Dimethylamine Nitrosation
Joint Authors
Liu, Qing Ming
Xu, Long
Sun, Zhi
Zhong, Ru Gang
Liu, Yong Dong
Wu, Fengchang
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Buffer solutions were widely used for almost all the investigations concerning N-nitrosodimethylamine (NDMA), a member of powerful mutagenic and carcinogenic compounds which are ubiquitous in the environment.
However, whether or how the buffer matrixes influence NDMA formation is still unknown.
The effect of buffer solutions on NDMA formation from the nitrosation of dimethylamine (DMA) by nitrite (NaNO2) was investigated at pH 6.4 in four kinds of buffer solutions, that is, Na2HPO4/C6H8O7, Na3(C6H5O7)/C6H8O7, NaH2PO4/NaOH, and NaH2PO4/Na2HPO4.
Our observations demonstrate an unexpected inhibitory effect of the buffer solutions on NDMA formation and the phosphate buffer plays a more significant role in inhibiting NDMA formation compared to the citrate buffer.
Moreover, the amount of the phosphate in the buffer was also found to greatly impact the formation of NDMA.
A further investigation indicates that it is the interaction between NaH2PO4 and reactant NaNO2 rather than DMA that leads to the inhibitory effect of phosphate buffer during the DMA nitrosation reaction.
This study expands the understanding of the influence of buffer solution on nitrosamines formation through the nitrosation pathway and further gives a hint for water plants to reduce the formation of nitrosamines.
American Psychological Association (APA)
Xu, Long& Sun, Zhi& Liu, Qing Ming& Liu, Yong Dong& Zhong, Ru Gang& Wu, Fengchang. 2012. The Influence of Phosphate Buffer on the Formation of N-Nitrosodimethylamine from Dimethylamine Nitrosation. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-500613
Modern Language Association (MLA)
Xu, Long…[et al.]. The Influence of Phosphate Buffer on the Formation of N-Nitrosodimethylamine from Dimethylamine Nitrosation. Journal of Chemistry No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-500613
American Medical Association (AMA)
Xu, Long& Sun, Zhi& Liu, Qing Ming& Liu, Yong Dong& Zhong, Ru Gang& Wu, Fengchang. The Influence of Phosphate Buffer on the Formation of N-Nitrosodimethylamine from Dimethylamine Nitrosation. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-500613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500613