Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity
Joint Authors
Giorgino, Francesco
Natalicchio, Annalisa
Perrini, Sebastio
Laviola, Luigi
Leonardini, Anna
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
PPARγ activation in type 2 diabetic patients results in a marked improvement in insulin and glucose parameters, resulting from an improvement of whole-body insulin sensitivity.
Adipose tissue is the major mediator of PPARγ action on insulin sensitivity.
PPARγ activation in mature adipocytes induces the expression of a number of genes involved in the insulin signaling cascade, thereby improving insulin sensitivity.
PPARγ is the master regulator of adipogenesis, thereby stimulating the production of small insulin-sensitive adipocytes.
In addition to its importance in adipogenesis, PPARγ plays an important role in regulating lipid, metabolism in mature adipocytes by increasing fatty acid trapping.
Finally, adipose tissue produces several cytokines that regulate energy homeostasis, lipid and glucose metabolism.
Disturbances in the production of these factors may contribute to metabolic abnormalities, and PPARγ activation is also associated with beneficial effects on expression and secretion of a whole range of cytokines.
American Psychological Association (APA)
Leonardini, Anna& Laviola, Luigi& Perrini, Sebastio& Natalicchio, Annalisa& Giorgino, Francesco. 2010. Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity. PPAR Research،Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-500614
Modern Language Association (MLA)
Leonardini, Anna…[et al.]. Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity. PPAR Research No. 2009 (2009), pp.1-12.
https://search.emarefa.net/detail/BIM-500614
American Medical Association (AMA)
Leonardini, Anna& Laviola, Luigi& Perrini, Sebastio& Natalicchio, Annalisa& Giorgino, Francesco. Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity. PPAR Research. 2010. Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-500614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500614