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Lenalidomide and Dexamethasone for a Patient of POEMS Syndrome Presenting with Massive Ascites
Joint Authors
Matsunaga, Hitomi
Inui, Yoshiaki
Nakata, Keiichi
Fujii, Naohiko
Oka, Kazumasa
Iwama, Yuki
Narahara, Hiroyuki
Yasunaga, Yuichi
Ueda, Shuji
Kataoka, Seiko
Kawata, Sumio
Yonemoto, Sayoko
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-19
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
POEMS syndrome is a multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes.
POEMS syndrome is a rare cause of refractory ascites.
We report the case of a patient with POEMS syndrome presenting with massive ascites who was treated with very-low-dose lenalidomide and dexamethasone.
A 57-year-old Japanese man was admitted to our hospital with pleural effusion, massive ascites, and leg edema.
The diagnosis of POEMS syndrome was made based on the combination of the following findings: peripheral neuropathy, organomegaly, endocrinopathy, serum monoclonal protein elevation, skin changes, plasma VEGF elevation, and evidence of extravascular volume overload.
Renal dysfunction induced by biopsy-proven renal involvement of POEMS syndrome was observed.
Massive ascites of the patient dramatically diminished with long-time treatment of very-low-dose lenalidomide and dexamethasone.
Lenalidomide seems to be a very promising therapy for POEMS syndrome presenting with extravascular volume overload such as edema, pleural effusion, and ascites.
Very-low-dose lenalidomide might be effective especially for the patients with POEMS-related nephropathy.
American Psychological Association (APA)
Ueda, Shuji& Yonemoto, Sayoko& Oka, Kazumasa& Fujii, Naohiko& Nakata, Keiichi& Matsunaga, Hitomi…[et al.]. 2014. Lenalidomide and Dexamethasone for a Patient of POEMS Syndrome Presenting with Massive Ascites. Case Reports in Hematology،Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-500615
Modern Language Association (MLA)
Ueda, Shuji…[et al.]. Lenalidomide and Dexamethasone for a Patient of POEMS Syndrome Presenting with Massive Ascites. Case Reports in Hematology No. 2014 (2014), pp.1-3.
https://search.emarefa.net/detail/BIM-500615
American Medical Association (AMA)
Ueda, Shuji& Yonemoto, Sayoko& Oka, Kazumasa& Fujii, Naohiko& Nakata, Keiichi& Matsunaga, Hitomi…[et al.]. Lenalidomide and Dexamethasone for a Patient of POEMS Syndrome Presenting with Massive Ascites. Case Reports in Hematology. 2014. Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-500615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500615