ConservationMutation in the Splice Sites of Cytokine Receptor Genes of Mouse and Human
Joint Authors
Calvello, Rosa
Panaro, Maria Antonietta
Cianciulli, Antonia
Source
International Journal of Evolutionary Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Conservation/mutation in the intronic initial and terminal hexanucleotides was studied in 26 orthologous cytokine receptor genes of Mouse and Human.
Introns began and ended with the canonical dinucleotides GT and AG, respectively.
Identical configurations were found in 57% of the 5′ hexanucleotides and 28% of the 3′ hexanucleotides.
The actual conservation percentages of the individual variable nucleotides at each position in the hexanucleotides were determined, and the theoretical rates of conservation of groups of three nucleotides were calculated under the hypothesis of a mutual evolutionary independence of the neighboring nucleotides (random association).
Analysis of the actual conservation of groups of variable nucleotides showed that, at 5′, GTGAGx was significantly more expressed and GTAAGx was significantly less expressed, as compared to the random association.
At 3′, TTTxAG and xTGCAG were overexpressed as compared to a random association.
Study of Mouse and Human transcript variants involving the splice sites showed that most variants were not inherited from the common ancestor but emerged during the process of speciation.
In some variants the silencing of a terminal hexanucleotide determined skipping of the downstream exon; in other variants the constitutive splicing hexanucleotide was replaced by another potential, in-frame, splicing hexanucleotide, leading to alterations of exon lengths.
American Psychological Association (APA)
Calvello, Rosa& Cianciulli, Antonia& Panaro, Maria Antonietta. 2013. ConservationMutation in the Splice Sites of Cytokine Receptor Genes of Mouse and Human. International Journal of Evolutionary Biology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-500617
Modern Language Association (MLA)
Calvello, Rosa…[et al.]. ConservationMutation in the Splice Sites of Cytokine Receptor Genes of Mouse and Human. International Journal of Evolutionary Biology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-500617
American Medical Association (AMA)
Calvello, Rosa& Cianciulli, Antonia& Panaro, Maria Antonietta. ConservationMutation in the Splice Sites of Cytokine Receptor Genes of Mouse and Human. International Journal of Evolutionary Biology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-500617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500617