Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients : Increase in Lipid Peroxidation and SOD Activity
Joint Authors
Vasconcelos, Sandra Mary L.
Rabelo, Luíza A.
Gelain, Daniel Pens
Goulart, Marília Oliveira F.
Guedes, Glaucevane da S.
Pires, André S.
Bandeira, Suziy de M.
Fonseca, Lucas José S. da
Fonseca Moreira, José Cláudio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
This study evaluated the oxidative stress through enzymatic and nonenzymatic biomarkers in diabetic patients with and without hypertension and prediabetics.
The SOD and CAT (in erythrocytes) and GPx (in plasma) enzymatic activities, plasma levels of lipid peroxidation, and total thiols were measured in the blood of 55 subjects with type 2 diabetes and 38 subjects without diabetes (9 pre-diabetics and 29 controls) aged 40–86 years.
The total SOD activity and the lipid peroxidation were higher in diabetics compared to nondiabetics.
In stratified groups, the total SOD activity was different for the hypertensive diabetics compared to the prediabetics and normotensive controls.
Lipid peroxidation was significantly higher in both groups of diabetics (hypertensive and normotensive) compared to prediabetic groups and hypertensive and normotensive controls.
There was no significant difference in the CAT and GPx activities, as well as in the concentration of total thiols in the groups studied.
Present data strongly suggest the involvement of oxidative stress in the pathophysiology of diabetes, revealing that the increased lipid peroxidation has a close relationship with high glucose levels, as observed by the fasting glucose and HbA1c levels.
The results evidence the correlation between lipid peroxidation and DM, irrespective of the presence of hypertension.
American Psychological Association (APA)
Bandeira, Suziy de M.& Guedes, Glaucevane da S.& Fonseca, Lucas José S. da& Pires, André S.& Gelain, Daniel Pens& Fonseca Moreira, José Cláudio…[et al.]. 2012. Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients : Increase in Lipid Peroxidation and SOD Activity. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-500650
Modern Language Association (MLA)
Bandeira, Suziy de M.…[et al.]. Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients : Increase in Lipid Peroxidation and SOD Activity. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-500650
American Medical Association (AMA)
Bandeira, Suziy de M.& Guedes, Glaucevane da S.& Fonseca, Lucas José S. da& Pires, André S.& Gelain, Daniel Pens& Fonseca Moreira, José Cláudio…[et al.]. Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients : Increase in Lipid Peroxidation and SOD Activity. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-500650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500650