Subarachnoid Hemorrhage, Spreading Depolarizations and Impaired Neurovascular Coupling
Joint Authors
Koide, Masayo
Ayata, Cenk
Sukhotinsky, Inna
Wellman, George C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aneurysmal subarachnoid hemorrhage (SAH) has devastating consequences on brain function including profound effects on communication between neurons and the vasculature leading to cerebral ischemia.
Physiologically, neurovascular coupling represents a focal increase in cerebral blood flow to meet increased metabolic demand of neurons within active regions of the brain.
Neurovascular coupling is an ongoing process involving coordinated activity of the neurovascular unit—neurons, astrocytes, and parenchymal arterioles.
Neuronal activity can also influence cerebral blood flow on a larger scale.
Spreading depolarizations (SD) are self-propagating waves of neuronal depolarization and are observed during migraine, traumatic brain injury, and stroke.
Typically, SD is associated with increased cerebral blood flow.
Emerging evidence indicates that SAH causes inversion of neurovascular communication on both the local and global level.
In contrast to other events causing SD, SAH-induced SD decreases rather than increases cerebral blood flow.
Further, at the level of the neurovascular unit, SAH causes an inversion of neurovascular coupling from vasodilation to vasoconstriction.
Global ischemia can also adversely affect the neurovascular response.
Here, we summarize current knowledge regarding the impact of SAH and global ischemia on neurovascular communication.
A mechanistic understanding of these events should provide novel strategies to treat these neurovascular disorders.
American Psychological Association (APA)
Koide, Masayo& Sukhotinsky, Inna& Ayata, Cenk& Wellman, George C.. 2013. Subarachnoid Hemorrhage, Spreading Depolarizations and Impaired Neurovascular Coupling. Stroke Research and Treatment،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-500655
Modern Language Association (MLA)
Koide, Masayo…[et al.]. Subarachnoid Hemorrhage, Spreading Depolarizations and Impaired Neurovascular Coupling. Stroke Research and Treatment No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-500655
American Medical Association (AMA)
Koide, Masayo& Sukhotinsky, Inna& Ayata, Cenk& Wellman, George C.. Subarachnoid Hemorrhage, Spreading Depolarizations and Impaired Neurovascular Coupling. Stroke Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-500655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500655