Chronic Sleep Disturbance Impairs Glucose Homeostasis in Rats
Joint Authors
Barf, R. Paulien
Scheurink, Anton J. W.
Meerlo, Peter
Source
International Journal of Endocrinology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Epidemiological studies have shown an association between short or disrupted sleep and an increased risk for metabolic disorders.
To assess a possible causal relationship, we examined the effects of experimental sleep disturbance on glucose regulation in Wistar rats under controlled laboratory conditions.
Three groups of animals were used: a sleep restriction group (RS), a group subjected to moderate sleep disturbance without restriction of sleep time (DS), and a home cage control group.
To establish changes in glucose regulation, animals were subjected to intravenous glucose tolerance tests (IVGTTs) before and after 1 or 8 days of sleep restriction or disturbance.
Data show that both RS and DS reduce body weight without affecting food intake and also lead to hyperglycemia and decreased insulin levels during an IVGTT.
Acute sleep disturbance also caused hyperglycemia during an IVGTT, yet, without affecting the insulin response.
In conclusion, both moderate and severe disturbances of sleep markedly affect glucose homeostasis and body weight control.
American Psychological Association (APA)
Barf, R. Paulien& Meerlo, Peter& Scheurink, Anton J. W.. 2010. Chronic Sleep Disturbance Impairs Glucose Homeostasis in Rats. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-500663
Modern Language Association (MLA)
Barf, R. Paulien…[et al.]. Chronic Sleep Disturbance Impairs Glucose Homeostasis in Rats. International Journal of Endocrinology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-500663
American Medical Association (AMA)
Barf, R. Paulien& Meerlo, Peter& Scheurink, Anton J. W.. Chronic Sleep Disturbance Impairs Glucose Homeostasis in Rats. International Journal of Endocrinology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-500663
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500663