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Th17 Response and Inflammatory Autoimmune Diseases
Joint Authors
Waite, Janelle C.
Skokos, Dimitris
Source
International Journal of Inflammation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The proinflammatory activity of T helper 17 (Th17) cells can be beneficial to the host during infection.
However, uncontrolled or inappropriate Th17 activation has been linked to several autoimmune and autoinflammatory pathologies.
Indeed, preclinical and clinical data show that Th17 cells are associated with several autoimmune diseases such as arthritis, multiple sclerosis, psoriasis, and lupus.
Furthermore, targeting the interleukin-17 (IL-17) pathway has attenuated disease severity in preclinical models of autoimmune diseases.
Interestingly, a recent report brings to light a potential role for Th17 cells in the autoinflammatory disorder adult-onset Still's disease (AOSD).
Whether Th17 cells are the cause or are directly involved in AOSD remains to be shown.
In this paper, we discuss the biology of Th17 cells, their role in autoimmune disease development, and in AOSD in particular, as well as the growing interest of the pharmaceutical industry in their use as therapeutic targets.
American Psychological Association (APA)
Waite, Janelle C.& Skokos, Dimitris. 2011. Th17 Response and Inflammatory Autoimmune Diseases. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-500670
Modern Language Association (MLA)
Waite, Janelle C.& Skokos, Dimitris. Th17 Response and Inflammatory Autoimmune Diseases. International Journal of Inflammation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-500670
American Medical Association (AMA)
Waite, Janelle C.& Skokos, Dimitris. Th17 Response and Inflammatory Autoimmune Diseases. International Journal of Inflammation. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-500670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500670