Redox Status Is Critical for Stemness in Skin Equivalents
Joint Authors
Choi, Hye-Ryung
Na, Jung-Im
Kang, Youn-A
Shin, Jung-Won
Huh, Chang-Hun
Park, Kyoung-Chan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The skin is constantly exposed to environmental oxidative stress.
Skin equivalent (SE) models are three-dimensional systems in which cell-cell or cell-matrix interactions can be investigated.
In this study, the effects of vitamin C or plant extracts with high antioxidant activities were tested.
There was no significant difference in the epidermal thickness, but the basal cells became cuboidal when vitamin C or plant extracts were supplemented.
Furthermore, immunohistochemical staining showed linear and intense staining of α6 and β1 integrin along the basement membrane in vitamin C or plant extract treated models.
The p63 and PCNA were also stained.
Results showed that the number of p63 and PCNA positive cells was higher in the vitamin C or plant extract treated models than in the control SEs.
Although the relationship between oxidative stress and stem cells is not known, our results suggest that redox status affects the stemness and the proliferative potential of epidermal basal cells by modulating microenvironment to epidermal basal stem cells.
American Psychological Association (APA)
Choi, Hye-Ryung& Kang, Youn-A& Shin, Jung-Won& Na, Jung-Im& Huh, Chang-Hun& Park, Kyoung-Chan. 2012. Redox Status Is Critical for Stemness in Skin Equivalents. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-500688
Modern Language Association (MLA)
Choi, Hye-Ryung…[et al.]. Redox Status Is Critical for Stemness in Skin Equivalents. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-500688
American Medical Association (AMA)
Choi, Hye-Ryung& Kang, Youn-A& Shin, Jung-Won& Na, Jung-Im& Huh, Chang-Hun& Park, Kyoung-Chan. Redox Status Is Critical for Stemness in Skin Equivalents. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-500688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500688