Induced Brain Plasticity after a Facilitation Programme for Autobiographical Memory in Multiple Sclerosis : A Preliminary Study
Joint Authors
Botzung, Anne
Sellal, François
Blanc, Frédéric
Gounot, Daniel
Manning, Liliann
Ernst, Alexandra
de Seze, Jerome
Source
Multiple Sclerosis International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This preliminary study tackles the assessment and treatment of autobiographical memory (AbM) in relapsing-remitting multiple sclerosis (RR-MS) patients.
Our aim was to investigate cerebral activation changes, following clinical improvement of AbM due to a cognitive training based on mental visual imagery (MVI).
We assessed AbM using the Autobiographical Interview (AI) in eight patients and 15 controls.
The latter subjects established normative data.
The eight patients showed selective defective performance on the AI.
Four patients were trained cognitively and underwent pre- and post-AI and fMRI.
The remaining four patients took a second AI, at the same interval, but with no intervention in between.
Results showed a significant improvement of AbM performance after the facilitation programme that could not be explained by learning effects since the AI scores remained stable between the two assessments in the second group of patients.
As expected, AbM improvement was accompanied by an increased cerebral activity in posterior cerebral regions in post-facilitation fMRI examination.
We interpret this activation changes in terms of reflecting the emphasis made on the role of MVI in memory retrieval through the facilitation programme.
These preliminary significant clinical and neuroimaging changes suggest the beneficial effects of this technique to alleviate AbM retrieval deficit in MS patients.
American Psychological Association (APA)
Ernst, Alexandra& Botzung, Anne& Gounot, Daniel& Sellal, François& Blanc, Frédéric& de Seze, Jerome…[et al.]. 2012. Induced Brain Plasticity after a Facilitation Programme for Autobiographical Memory in Multiple Sclerosis : A Preliminary Study. Multiple Sclerosis International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-500729
Modern Language Association (MLA)
Ernst, Alexandra…[et al.]. Induced Brain Plasticity after a Facilitation Programme for Autobiographical Memory in Multiple Sclerosis : A Preliminary Study. Multiple Sclerosis International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-500729
American Medical Association (AMA)
Ernst, Alexandra& Botzung, Anne& Gounot, Daniel& Sellal, François& Blanc, Frédéric& de Seze, Jerome…[et al.]. Induced Brain Plasticity after a Facilitation Programme for Autobiographical Memory in Multiple Sclerosis : A Preliminary Study. Multiple Sclerosis International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-500729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500729