Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma

Abstract EN

Chondrosarcomas are among the most malignant skeletal tumors.

Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients.

In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma.

We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases.

Moreover, we reveal a signature of “multifunctional” genes that are expressed in all metastatic lung lesions.

Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.