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Heterogeneous Responses to Antioxidants in Noradrenergic Neurons of the Locus Coeruleus Indicate Differing Susceptibility to Free Radical Content
Joint Authors
van Helden, Dirk F.
Callister, Robert J.
Gravina, Fernanda S.
Lim, Rebecca
Brichta, Alan M.
Birnfeld de Oliveira, Ramatis
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The present study investigated the effects of the antioxidants trolox and dithiothreitol (DTT) on mouse Locus coeruleus (LC) neurons.
Electrophysiological measurement of action potential discharge and whole cell current responses in the presence of each antioxidant suggested that there are three neuronal subpopulations within the LC.
In current clamp experiments, most neurons (55%; 6/11) did not respond to the antioxidants.
The remaining neurons exhibited either hyperpolarization and decreased firing rate (27%; 3/11) or depolarization and increased firing rate (18%; 2/11).
Calcium and JC-1 imaging demonstrated that these effects did not change intracellular Ca2+ concentration but may influence mitochondrial function as both antioxidant treatments modulated mitochondrial membrane potential.
These suggest that the antioxidant-sensitive subpopulations of LC neurons may be more susceptible to oxidative stress (e.g., due to ATP depletion and/or overactivation of Ca2+-dependent pathways).
Indeed it may be that this subpopulation of LC neurons is preferentially destroyed in neurological pathologies such as Parkinson’s disease.
If this is the case, there may be a protective role for antioxidant therapies.
American Psychological Association (APA)
Birnfeld de Oliveira, Ramatis& Gravina, Fernanda S.& Lim, Rebecca& Brichta, Alan M.& Callister, Robert J.& van Helden, Dirk F.. 2012. Heterogeneous Responses to Antioxidants in Noradrenergic Neurons of the Locus Coeruleus Indicate Differing Susceptibility to Free Radical Content. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-500736
Modern Language Association (MLA)
Birnfeld de Oliveira, Ramatis…[et al.]. Heterogeneous Responses to Antioxidants in Noradrenergic Neurons of the Locus Coeruleus Indicate Differing Susceptibility to Free Radical Content. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-500736
American Medical Association (AMA)
Birnfeld de Oliveira, Ramatis& Gravina, Fernanda S.& Lim, Rebecca& Brichta, Alan M.& Callister, Robert J.& van Helden, Dirk F.. Heterogeneous Responses to Antioxidants in Noradrenergic Neurons of the Locus Coeruleus Indicate Differing Susceptibility to Free Radical Content. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-500736
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500736