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Evaluation of Human Telomeric G-Quadruplexes : The Influence of Overhanging Sequences on Quadruplex Stability and Folding
Joint Authors
Viglasky, Viktor
Bauer, Lubos
Javorsky, Peter
Tluckova, Katarina
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To date, various G-quadruplex structures have been reported in human telomeric sequences.
Human telomeric repeats can form many topological structures depending on conditions and on base modification; parallel, antiparallel, and hybrid forms.
The effect of salts and some specific ligands on conformational switches between different conformers is known, but the influence of protruding sequences has rarely been discussed.
In this paper, we analyze different quadruplex-forming oligomers derived from human telomeric sequences which contain 3′- and 5′-protruding nucleotides, not usually associated with the G-quadruplex motif.
The study was performed using electrophoresis, CD, and UV spectroscopies.
The major findings are (i) protruding nucleotides destabilize the G-quadruplex structure, and (ii) overhanging sequences influence the folding of the quadruplex.
American Psychological Association (APA)
Viglasky, Viktor& Bauer, Lubos& Tluckova, Katarina& Javorsky, Peter. 2010. Evaluation of Human Telomeric G-Quadruplexes : The Influence of Overhanging Sequences on Quadruplex Stability and Folding. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-500739
Modern Language Association (MLA)
Viglasky, Viktor…[et al.]. Evaluation of Human Telomeric G-Quadruplexes : The Influence of Overhanging Sequences on Quadruplex Stability and Folding. Journal of Nucleic Acids No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-500739
American Medical Association (AMA)
Viglasky, Viktor& Bauer, Lubos& Tluckova, Katarina& Javorsky, Peter. Evaluation of Human Telomeric G-Quadruplexes : The Influence of Overhanging Sequences on Quadruplex Stability and Folding. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-500739
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500739