Synthetic Peptides as Structural Maquettes of Angiotensin-I Converting Enzyme Catalytic Sites
Joint Authors
Pairas, George
Galanis, Athanassios S.
Manessi-Zoupa, Evy
Cordopatis, Paul
Spyranti, Zinovia
Spyroulias, Georgios A.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The rational design of synthetic peptides is proposed as an efficient strategy for the structural investigation of crucial protein domains difficult to be produced.
Only after half a century since the function of ACE was first reported, was its crystal structure solved.
The main obstacle to be overcome for the determination of the high resolution structure was the crystallization of the highly hydrophobic transmembrane domain.
Following our previous work, synthetic peptides and Zinc(II) metal ions are used to build structural maquettes of the two Zn-catalytic active sites of the ACE somatic isoform.
Structural investigations of the synthetic peptides, representing the two different somatic isoform active sites, through circular dichroism and NMR experiments are reported.
American Psychological Association (APA)
Spyranti, Zinovia& Galanis, Athanassios S.& Pairas, George& Spyroulias, Georgios A.& Manessi-Zoupa, Evy& Cordopatis, Paul. 2010. Synthetic Peptides as Structural Maquettes of Angiotensin-I Converting Enzyme Catalytic Sites. Bioinorganic Chemistry and Applications،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-500756
Modern Language Association (MLA)
Spyranti, Zinovia…[et al.]. Synthetic Peptides as Structural Maquettes of Angiotensin-I Converting Enzyme Catalytic Sites. Bioinorganic Chemistry and Applications No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-500756
American Medical Association (AMA)
Spyranti, Zinovia& Galanis, Athanassios S.& Pairas, George& Spyroulias, Georgios A.& Manessi-Zoupa, Evy& Cordopatis, Paul. Synthetic Peptides as Structural Maquettes of Angiotensin-I Converting Enzyme Catalytic Sites. Bioinorganic Chemistry and Applications. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-500756
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500756