Solubility Enhancement of Etoricoxib by Cosolvency Approach

Joint Authors

Panigrahi, Prachi Prava
Nayak, Amit Kumar

Source

ISRN Physical Chemistry

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-04-18

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Physics
Chemistry

Abstract EN

The purpose of the present study was to examine and compare the cosolvency using three different cosolvents, namely PEG 400, PG, and glycerin on the aqueous solubility enhancement of a poorly aqueous soluble drug, etoricoxib, since solubilization of nonpolar drugs constitutes one of the important tasks in the formulation design of liquid dosage forms.

The aqueous solubility of etoricoxib was 0.0767±0.0018 mg/mL, which was significantly improved by the addition of PEG 400, PG, and glycerin as cosolvents.

It was scrutinized that the less-polar solvents were found to increase the aqueous solubility by greater extent, thus accentuating hydrophobic interaction mechanism.

Among various solvent-cosolvent blends investigated, water-PEG 400 showed highest solubilization potential.

Thus, the study generated an important array of data to compare the effect of these cosolvents on the aqueous solubility of etoricoxib.

American Psychological Association (APA)

Nayak, Amit Kumar& Panigrahi, Prachi Prava. 2012. Solubility Enhancement of Etoricoxib by Cosolvency Approach. ISRN Physical Chemistry،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-500768

Modern Language Association (MLA)

Nayak, Amit Kumar& Panigrahi, Prachi Prava. Solubility Enhancement of Etoricoxib by Cosolvency Approach. ISRN Physical Chemistry No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-500768

American Medical Association (AMA)

Nayak, Amit Kumar& Panigrahi, Prachi Prava. Solubility Enhancement of Etoricoxib by Cosolvency Approach. ISRN Physical Chemistry. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-500768

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-500768