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The Cardioprotective Effects of Citric Acid and L-Malic Acid on Myocardial IschemiaReperfusion Injury
Joint Authors
Lin, Chengren
Tang, Xilan
Li, Peng
Hou, Jincai
Zheng, Yongqiu
Dong, Wei
Liu, Jianxun
Li, Dan
Li, Lei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Organic acids in Chinese herbs, the long-neglected components, have been reported to possess antioxidant, anti-inflammatory, and antiplatelet aggregation activities; thus they may have potentially protective effect on ischemic heart disease.
Therefore, this study aims to investigate the protective effects of two organic acids, that is, citric acid and L-malic acid, which are the main components of Fructus Choerospondiatis, on myocardial ischemia/reperfusion injury and the underlying mechanisms.
In in vivo rat model of myocardial ischemia/reperfusion injury, we found that treatments with citric acid and L-malic acid significantly reduced myocardial infarct size, serum levels of TNF-α, and platelet aggregation.
In vitro experiments revealed that both citric acid and L-malic acid significantly reduced LDH release, decreased apoptotic rate, downregulated the expression of cleaved caspase-3, and upregulated the expression of phosphorylated Akt in primary neonatal rat cardiomyocytes subjected to hypoxia/reoxygenation injury.
These results suggest that both citric acid and L-malic acid have protective effects on myocardial ischemia/reperfusion injury; the underlying mechanism may be related to their anti-inflammatory, antiplatelet aggregation and direct cardiomyocyte protective effects.
These results also demonstrate that organic acids, besides flavonoids, may also be the major active ingredient of Fructus Choerospondiatis responsible for its cardioprotective effects and should be attached great importance in the therapy of ischemic heart disease.
American Psychological Association (APA)
Tang, Xilan& Liu, Jianxun& Dong, Wei& Li, Peng& Li, Lei& Lin, Chengren…[et al.]. 2013. The Cardioprotective Effects of Citric Acid and L-Malic Acid on Myocardial IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-500774
Modern Language Association (MLA)
Tang, Xilan…[et al.]. The Cardioprotective Effects of Citric Acid and L-Malic Acid on Myocardial IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-500774
American Medical Association (AMA)
Tang, Xilan& Liu, Jianxun& Dong, Wei& Li, Peng& Li, Lei& Lin, Chengren…[et al.]. The Cardioprotective Effects of Citric Acid and L-Malic Acid on Myocardial IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-500774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500774