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Natural Progression of Biochemical Markers of Biliary Tract Obstruction in Patients with Gallstone Pancreatitis
Joint Authors
Mason, Rodney J.
Berne, Thomas V.
Chan, Sirius
Petrosyan, Mikael
Estrada, Joaquin J.
Rosen, Heather
Source
Gastroenterology Research and Practice
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The presenting pattern and natural progression of biochemical markers of biliary tract obstruction in patients with gallstone pancreatitis have not been elucidated.
We analyzed serial values of bilirubin levels following admission to discharge in 143 patients.
Ninety-four of patients demonstrated a Decrescendo (falling) pattern of bilirubin levels from admission until normalization at 21 hours (median).
Forty-nine patients demonstrated a Crescendo-Decrescendo (initially rising) pattern with peak levels of bilirubin occurring at 39 hours after admission followed by a subsequent normalization after a median of 119 hours.
Patients in the Decrescendo group were significantly younger (33 versus 41 years, P=.02) and more patients had experienced symptoms for greater than 48 hours (65% versus 47%, P=.05).
Ten percent of patients in the Decrescendo group and 29% of patients in the Crescendo-Decrescendo group underwent ERCP (P=.02).
Normalization of biochemical markers after ERCP was significantly delayed in both groups compared to no ERCP.
Older patients present earlier, with higher bilirubin levels and normalize slower than younger patients, perhaps due to fibrosis of the ampulla and decreased compliance of the common bile duct.
Patients who disobstruct spontaneously (90%) normalize quicker than patients undergoing ERCP.
American Psychological Association (APA)
Petrosyan, Mikael& Estrada, Joaquin J.& Chan, Sirius& Rosen, Heather& Berne, Thomas V.& Mason, Rodney J.. 2009. Natural Progression of Biochemical Markers of Biliary Tract Obstruction in Patients with Gallstone Pancreatitis. Gastroenterology Research and Practice،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-500781
Modern Language Association (MLA)
Petrosyan, Mikael…[et al.]. Natural Progression of Biochemical Markers of Biliary Tract Obstruction in Patients with Gallstone Pancreatitis. Gastroenterology Research and Practice No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-500781
American Medical Association (AMA)
Petrosyan, Mikael& Estrada, Joaquin J.& Chan, Sirius& Rosen, Heather& Berne, Thomas V.& Mason, Rodney J.. Natural Progression of Biochemical Markers of Biliary Tract Obstruction in Patients with Gallstone Pancreatitis. Gastroenterology Research and Practice. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-500781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500781