Abarema cochliacarpos Extract Decreases the Inflammatory Process and Skeletal Muscle Injury Induced by Bothrops leucurus Venom
Joint Authors
Estevam, Charles Santos
Santos, Daiana Do Carmo
Maria, Durvanei Augusto
da Silva Almeida, Jackson Roberto Guedes
Santos Dias, Antônio
Pereira de Oliveira, Aldeídia
Araújo, Adriano Antunes de Souza
Quintans Júnior, Lucindo José
Santos, Márcio Roberto Viana
Guimarães, Adriana Gibara
Melo, Paulo A.
Saturnino-Oliveira, Jeison
Monteiro-Machado, Marcos
Lucca Júnior, Waldecy De
Oliveira, Rita de Cássia Meneses
Tomaz, Marcelo Amorim
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Snakebites are a public health problem, especially in tropical countries.
However, treatment with antivenom has limited effectiveness against venoms’ local effects.
Here, we investigated the ability of Abarema cochliacarpos hydroethanolic extract (EAc) to protect mice against injection of Bothrops leucurus venom.
Swiss mice received perimuscular venom injection and were subsequently treated orally with EAc in different doses.
Treatment with EAc 100, 200, and 400 mg/kg reduced the edema induced by B.
leucurus in 1%, 13%, and 39%, respectively.
Although lower doses showed no antihypernociceptive effect in the Von Frey test, the higher dose significantly reduced hyperalgesia induced by the venom.
Antimyotoxic activity of EAc was also observed by microscopy assessment, with treated muscles presenting preserved structures, decreased edema, and inflammatory infiltrate as compared to untreated ones.
Finally, on the rotarod test, the treated mice showed better motor function, once muscle fibers were preserved and there were less edema and pain.
Treated mice could stand four times more time on the rotating rod than untreated ones.
Our results have shown that EAc presented relevant activities against injection of B.
leucurus venom in mice, suggesting that it can be considered as an adjuvant in the treatment of envenomation.
American Psychological Association (APA)
Saturnino-Oliveira, Jeison& Santos, Daiana Do Carmo& Guimarães, Adriana Gibara& Santos Dias, Antônio& Tomaz, Marcelo Amorim& Monteiro-Machado, Marcos…[et al.]. 2014. Abarema cochliacarpos Extract Decreases the Inflammatory Process and Skeletal Muscle Injury Induced by Bothrops leucurus Venom. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-500782
Modern Language Association (MLA)
Saturnino-Oliveira, Jeison…[et al.]. Abarema cochliacarpos Extract Decreases the Inflammatory Process and Skeletal Muscle Injury Induced by Bothrops leucurus Venom. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-500782
American Medical Association (AMA)
Saturnino-Oliveira, Jeison& Santos, Daiana Do Carmo& Guimarães, Adriana Gibara& Santos Dias, Antônio& Tomaz, Marcelo Amorim& Monteiro-Machado, Marcos…[et al.]. Abarema cochliacarpos Extract Decreases the Inflammatory Process and Skeletal Muscle Injury Induced by Bothrops leucurus Venom. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-500782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500782