Effect of Glucose or Fat Challenge on Aspirin Resistance in Diabetes
Joint Authors
Davis-Gorman, Grace
Thomson, Stephen S.
Yassine, Hussein N.
McDonagh, Paul F.
Peterson, Justin
Stump, Craig S.
Source
International Journal of Endocrinology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aspirin has lower antiplatelet activity in diabetic patients.
Our aim is to study the roles of acute hyperglycemia and hyperlipidemia on aspirin function in diabetic subjects with and without cardiovascular disease.
Using urine thromboxane (pg/mg creatinine) and VerifyNow (Aspirin Resistance Measures-ARU), we investigated diabetic subjects during a 2-hour glucose challenge (n=49) or a 4-hour fat challenge (n=11).
All subjects were currently taking aspirin (81 or 325 mg).
After fat ingestion, urine thromboxane increased in all subjects (Mean ± SE before: after) (1209 ± 336: 1552 ±371, P=.01), while we noted a trend increase in VerifyNow measures (408±8: 431±18, P=.1).
The response to glucose ingestion was variable.
Diabetic subjects with cardiac disease and dyslipidemia increased thromboxane (1693±364: 2799 ± 513, P<.05) and VerifyNow (457.6 ± 22.3: 527.1 ± 25.8, P<.05) measures after glucose.
We conclude that saturated fat ingestion increases in vivo thromboxane production despite aspirin therapy.
American Psychological Association (APA)
Yassine, Hussein N.& Davis-Gorman, Grace& Stump, Craig S.& Thomson, Stephen S.& Peterson, Justin& McDonagh, Paul F.. 2011. Effect of Glucose or Fat Challenge on Aspirin Resistance in Diabetes. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-500795
Modern Language Association (MLA)
Yassine, Hussein N.…[et al.]. Effect of Glucose or Fat Challenge on Aspirin Resistance in Diabetes. International Journal of Endocrinology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-500795
American Medical Association (AMA)
Yassine, Hussein N.& Davis-Gorman, Grace& Stump, Craig S.& Thomson, Stephen S.& Peterson, Justin& McDonagh, Paul F.. Effect of Glucose or Fat Challenge on Aspirin Resistance in Diabetes. International Journal of Endocrinology. 2011. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-500795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500795