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Therapeutic Approaches to Delay the Onset of Alzheimer's Disease
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
The key cytopathologies in the brains of Alzheimer's disease (AD) patients include mitochondrial dysfunction and energy hypometabolism, which are likely caused by the accumulation of small aggregates of amyloid-β (Aβ) peptides.
Thus, targeting these two abnormalities of the AD brain may hold promising therapeutic value for delaying the onset of AD.
In his paper, we discuss two potential approaches to delay the onset of AD.
The first is the use of low dose of diaminophenothiazins (redox active agents) to prevent mitochondrial dysfunction and to attenuate energy hypometabolism.
Diaminophenothiazines enhance mitochondrial metabolic activity and heme synthesis, both key factors in intermediary metabolism of the AD brain.The second is to use the naturally occurring osmolytes to prevent the formation of toxic forms of Aβ and prevent oxidative stress.
Scientific evidence suggests that both approaches may change course of the basic mechanism of neurodegeneration in AD.
Osmolytes are brain metabolites which accumulate in tissues at relatively high concentrations following stress conditions.
Osmolytes enhance thermodynamic stability of proteins by stabilizing natively-folded protein conformation, thus preventing aggregation without perturbing other cellular processes.
Osmolytes may inhibit the formation of Aβ oligomers in vivo, thus preventing the formation of soluble oligomers.
The potential significance of combining diaminophenothiazins and osmolytes to treat AD is discussed.
American Psychological Association (APA)
Kumar, Raj& Atamna, Hani. 2011. Therapeutic Approaches to Delay the Onset of Alzheimer's Disease. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-500798
Modern Language Association (MLA)
Kumar, Raj& Atamna, Hani. Therapeutic Approaches to Delay the Onset of Alzheimer's Disease. Journal of Aging Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-500798
American Medical Association (AMA)
Kumar, Raj& Atamna, Hani. Therapeutic Approaches to Delay the Onset of Alzheimer's Disease. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-500798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500798