Apparent Diffusion Coefficient in Invasive Ductal Breast Carcinoma : Correlation with Detailed Histologic Features and the Enhancement Ratio on Dynamic Contrast-Enhanced MR Images
Joint Authors
Yasumori, Kotaro
Fujii, Teruhiko
Matsubayashi, Roka Namoto
Momosaki, Seiya
Muranaka, Toru
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To investigate the correlation of Apperent Diffusion Coefficient (ADC) values in invasive ductal breast carcinomas with detailed histologic features and enhancement ratios on dynamic contrast-enhanced MRI.
Methods and Materials.
Dynamic MR images and diffusion-weighted images (DWIs) of invasive ductal breast carcinomas were reviewed in 25 (26 lesions) women.
In each patient, DWI, T2WI, T1WI, and dynamic images were obtained.
The ADC values of the 26 carcinomas were calculated with b-factors of 0 and 1000 s/mm2 using echoplanar DWI.
Correlations of the ADC values were examined on dynamic MRI with enhancement ratios (early to delayed phase: E/D ratio) and detailed histologic findings for each lesion, including cellular density, the size of cancer nests, and architectural features of the stroma (broad, narrow, and delicate) between cancer nests.
Results.
The mean ADC was 0.915±0.151×10-3 mm2/sec.
Cellular density was significantly correlated with ADC values (P=.0184) and E/D ratios (P=.0315).
The ADC values were also significantly correlated to features of the stroma (broad to narrow, P=.0366).
Conclusion.
The findings suggest that DWIs reflect the growth patterns of carcinomas, including cellular density and architectural features of the stroma, and E/D ratios may also be closely correlated to cellular density.
American Psychological Association (APA)
Matsubayashi, Roka Namoto& Fujii, Teruhiko& Yasumori, Kotaro& Muranaka, Toru& Momosaki, Seiya. 2010. Apparent Diffusion Coefficient in Invasive Ductal Breast Carcinoma : Correlation with Detailed Histologic Features and the Enhancement Ratio on Dynamic Contrast-Enhanced MR Images. Journal of Oncology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-500812
Modern Language Association (MLA)
Matsubayashi, Roka Namoto…[et al.]. Apparent Diffusion Coefficient in Invasive Ductal Breast Carcinoma : Correlation with Detailed Histologic Features and the Enhancement Ratio on Dynamic Contrast-Enhanced MR Images. Journal of Oncology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-500812
American Medical Association (AMA)
Matsubayashi, Roka Namoto& Fujii, Teruhiko& Yasumori, Kotaro& Muranaka, Toru& Momosaki, Seiya. Apparent Diffusion Coefficient in Invasive Ductal Breast Carcinoma : Correlation with Detailed Histologic Features and the Enhancement Ratio on Dynamic Contrast-Enhanced MR Images. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-500812
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500812