Plant Polyphenols and Oxidative Metabolites of the Herbal Alkenylbenzene Methyleugenol Suppress Histone Deacetylase Activity in Human Colon Carcinoma Cells
Joint Authors
Chen, Chen
Lüske, Claudia
Groh, Isabel Anna Maria
Cartus, Alexander Thomas
Esselen, Melanie
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Evidence has been provided that diet and environmental factors directly influence epigenetic mechanisms associated with cancer development in humans.
The inhibition of histone deacetylase (HDAC) activity and the disruption of the HDAC complex have been recognized as a potent strategy for cancer therapy and chemoprevention.
In the present study, we investigated whether selected plant constituents affect HDAC activity or HDAC1 protein status in the human colon carcinoma cell line HT29.
The polyphenols (−)-epigallocatechin-3-gallate (EGCG) and genistein (GEN) as well as two oxidative methyleugenol (ME) metabolites were shown to inhibit HDAC activity in intact HT29 cells.
Concomitantly, a significant decrease of the HDAC1 protein level was observed after incubation with EGCG and GEN, whereas the investigated ME metabolites did not affect HDAC1 protein status.
In conclusion, dietary compounds were found to possess promising HDAC-inhibitory properties, contributing to epigenetic alterations in colon tumor cells, which should be taken into account in further risk/benefit assessments of polyphenols and alkenylbenzenes.
American Psychological Association (APA)
Groh, Isabel Anna Maria& Chen, Chen& Lüske, Claudia& Cartus, Alexander Thomas& Esselen, Melanie. 2013. Plant Polyphenols and Oxidative Metabolites of the Herbal Alkenylbenzene Methyleugenol Suppress Histone Deacetylase Activity in Human Colon Carcinoma Cells. Journal of Nutrition and Metabolism،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-500817
Modern Language Association (MLA)
Groh, Isabel Anna Maria…[et al.]. Plant Polyphenols and Oxidative Metabolites of the Herbal Alkenylbenzene Methyleugenol Suppress Histone Deacetylase Activity in Human Colon Carcinoma Cells. Journal of Nutrition and Metabolism No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-500817
American Medical Association (AMA)
Groh, Isabel Anna Maria& Chen, Chen& Lüske, Claudia& Cartus, Alexander Thomas& Esselen, Melanie. Plant Polyphenols and Oxidative Metabolites of the Herbal Alkenylbenzene Methyleugenol Suppress Histone Deacetylase Activity in Human Colon Carcinoma Cells. Journal of Nutrition and Metabolism. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-500817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500817