A Biomimetic Approach for the Creation of Two-Dimensional Microscale Surface Patterns : Creation of Isolated Immunological Synapses
Joint Authors
Mooney, David J.
Fahmy, Tarek M.
Stern, Eric
Source
International Journal of Biomaterials
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Current efforts in surface functionalization have not produced a robust technique capable of creating specific two-dimensional microscale geometrical arrays composed of multiple proteins.
Such a capability is desirable for engineering substrates in sensing and cell patterning applications where at least two different protein functionalities in a specific configuration are required.
Here we introduce a new approach for the creation of arrays of microscale geometries.
We demonstrate our approach with a biomimetic structure inspired by the immunological synapse, a cell-cell interfacial structure characterized by two concentric rings of proteins: an outer adhesion protein structure and an inner recognition ligand core.
The power of the technique lies in its ability to pattern any protein in any defined geometry as well as to create arrays in parallel.
American Psychological Association (APA)
Stern, Eric& Mooney, David J.& Fahmy, Tarek M.. 2009. A Biomimetic Approach for the Creation of Two-Dimensional Microscale Surface Patterns : Creation of Isolated Immunological Synapses. International Journal of Biomaterials،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-500827
Modern Language Association (MLA)
Stern, Eric…[et al.]. A Biomimetic Approach for the Creation of Two-Dimensional Microscale Surface Patterns : Creation of Isolated Immunological Synapses. International Journal of Biomaterials No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-500827
American Medical Association (AMA)
Stern, Eric& Mooney, David J.& Fahmy, Tarek M.. A Biomimetic Approach for the Creation of Two-Dimensional Microscale Surface Patterns : Creation of Isolated Immunological Synapses. International Journal of Biomaterials. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-500827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500827