Black Cohosh Hepatic Safety : Follow-Up of 107 Patients Consuming a Special Cimicifuga racemosa rhizome Herbal Extract and Review of Literature
Joint Authors
di Sarsina, Paolo Roberti
Gori, Luigi
Firenzuoli, Fabio
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
European Medicines Agency (EMEA) and the Committee on Herbal Medicinal Products (HMPC) on July 2006 have released an alert to get European sanitary authorities aware of 42 cases of suspected hepatotoxic reactions in patients consuming Cimicifuga racemosa rhizome.
In the public statement EMEA itself considered reliable as hepatotoxic reactions only four cases, on the base of RUCAM score: two were considered possible and two probable.
Lacking in almost all of them a precise description of cases, especially a botanical-chemical analysis of the suspected substance, we think there is no real proof of supposed C.
racemosa rhizome hepatotoxicity.
In our department we administer from about 10 years C.
racemosa as special herbal dry extract as single substance or mixed with other medicinal plants at the dose of 500–1000 mg daily, for treatment of menopause related disorders without any reported adverse effect.
After EMEA's official signal we have contacted all our patients using a C.
racemosa rhizome herbal extract continuously from more than 12 months to verify possible hepatotoxic effects.
We followed-up 107 women, and asked them by telephone (33/107) and/or after anamnesis and clinical examination (74/107) to undergo a blood sample examination.
In all the patients there was no sign of hepatic disease, or worsening of already altered but stable parameters.
We think on the base of these data and current literature C.
racemosa rhizome extract should not be considered a potential hepatotoxic substance.
American Psychological Association (APA)
Firenzuoli, Fabio& Gori, Luigi& di Sarsina, Paolo Roberti. 2010. Black Cohosh Hepatic Safety : Follow-Up of 107 Patients Consuming a Special Cimicifuga racemosa rhizome Herbal Extract and Review of Literature. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-500836
Modern Language Association (MLA)
Firenzuoli, Fabio…[et al.]. Black Cohosh Hepatic Safety : Follow-Up of 107 Patients Consuming a Special Cimicifuga racemosa rhizome Herbal Extract and Review of Literature. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-500836
American Medical Association (AMA)
Firenzuoli, Fabio& Gori, Luigi& di Sarsina, Paolo Roberti. Black Cohosh Hepatic Safety : Follow-Up of 107 Patients Consuming a Special Cimicifuga racemosa rhizome Herbal Extract and Review of Literature. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-500836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500836