![](/images/graphics-bg.png)
The Role of Specific Mitogen-Activated Protein Kinase Signaling Cascades in the Regulation of Steroidogenesis
Joint Authors
Manna, Pulak R.
Stocco, Douglas M.
Source
Journal of Signal Transduction
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Mitogen-activated protein kinases (MAPKs) comprise a family of serine/threonine kinases that are activated by a large variety of extracellular stimuli and play integral roles in controlling many cellular processes, from the cell surface to the nucleus.
The MAPK family includes four distinct MAPK cascades, that is, extracellular signal-regulated kinase 1/2 (ERK1/2), p38 MAPK, c-Jun N-terminal kinase or stress-activated protein kinase, and ERK5.
These MAPKs are essentially operated through three-tiered consecutive phosphorylation events catalyzed by a MAPK kinase kinase, a MAPK kinase, and a MAPK.
MAPKs lie in protein kinase cascades.
The MAPK signaling pathways have been demonstrated to be associated with events regulating the expression of the steroidogenic acute regulatory protein (StAR) and steroidogenesis in steroidogenic tissues.
However, it has become clear that the regulation of MAPK-dependent StAR expression and steroid synthesis is a complex process and is context dependent.
This paper summarizes the current level of understanding concerning the roles of the MAPK signaling cascades in the regulation of StAR expression and steroidogenesis in different steroidogenic cell models.
American Psychological Association (APA)
Manna, Pulak R.& Stocco, Douglas M.. 2011. The Role of Specific Mitogen-Activated Protein Kinase Signaling Cascades in the Regulation of Steroidogenesis. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-500861
Modern Language Association (MLA)
Manna, Pulak R.& Stocco, Douglas M.. The Role of Specific Mitogen-Activated Protein Kinase Signaling Cascades in the Regulation of Steroidogenesis. Journal of Signal Transduction No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-500861
American Medical Association (AMA)
Manna, Pulak R.& Stocco, Douglas M.. The Role of Specific Mitogen-Activated Protein Kinase Signaling Cascades in the Regulation of Steroidogenesis. Journal of Signal Transduction. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-500861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500861