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Diagnostic Value of Software-Based Image Fusion of Computed Tomography and F18-FDG PET Scans in Patients with Malignant Lymphoma
Joint Authors
Bale, R.
Uprimny, Christian
Kendler, D.
Virgolini, I.
Putzer, D.
Henninger, B.
Gunsilius, E.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Aim.
The purpose of this study was to evaluate the accuracy of 2-deoxy-2-[fluorine-18]fluoro-D-glucose (FDG) positron emission tomography (PET), computed tomography (CT), and software-based image fusion of both modalities in the imaging of non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD).
Methods.
77 patients with NHL (n=58) or HD (n=19) underwent a FDG PET scan, a contrast-enhanced CT, and a subsequent digital image fusion during initial staging or followup.
109 examinations of each modality were evaluated and compared to each other.
Conventional staging procedures, other imaging techniques, laboratory screening, and follow-up data constituted the reference standard for comparison with image fusion.
Sensitivity and specificity were calculated for CT and PET separately.
Results.
Sensitivity and specificity for detecting malignant lymphoma were 90% and 76% for CT and 94% and 91% for PET, respectively.
A lymph node region-based analysis (comprising 14 defined anatomical regions) revealed a sensitivity of 81% and a specificity of 97% for CT and 96% and 99% for FDG PET, respectively.
Only three of 109 image fusion findings needed further evaluation (false positive).
Conclusion.
Digital fusion of PET and CT improves the accuracy of staging, restaging, and therapy monitoring in patients with malignant lymphoma and may reduce the need for invasive diagnostic procedures.
American Psychological Association (APA)
Henninger, B.& Putzer, D.& Kendler, D.& Uprimny, Christian& Virgolini, I.& Gunsilius, E.…[et al.]. 2012. Diagnostic Value of Software-Based Image Fusion of Computed Tomography and F18-FDG PET Scans in Patients with Malignant Lymphoma. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-500869
Modern Language Association (MLA)
Henninger, B.…[et al.]. Diagnostic Value of Software-Based Image Fusion of Computed Tomography and F18-FDG PET Scans in Patients with Malignant Lymphoma. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-500869
American Medical Association (AMA)
Henninger, B.& Putzer, D.& Kendler, D.& Uprimny, Christian& Virgolini, I.& Gunsilius, E.…[et al.]. Diagnostic Value of Software-Based Image Fusion of Computed Tomography and F18-FDG PET Scans in Patients with Malignant Lymphoma. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-500869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500869