Study on HIF-1α Gene Translation in Psoriatic Epidermis with the Topical Treatment of Capsaicin Ointment

Abstract EN

Objective.

To investigate the mechanism of capsaicin in treating active psoriasis vulgaris.

Methods.

HIF-1α gene translation in active psoriatic lesions before and after 21-day treatment with capsaicin ointment was detected by in situ hybridization.

Results.

There was positive staining of HIF-1α gene in all the layers of psoriatic epidermis (100.0%) before the treatment with capsaicin ointment, but the dyeing in epidermis were reduced obviously (22.2%) after the treatment for 21 days.

Conclusion.

HIF-1α gene translation in psoriatic epidermis was downregulated after capsaicin treatment for 21 days.