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Prevention of Diabetic Nephropathy by Sulforaphane : Possible Role of Nrf2 Upregulation and Activation
Joint Authors
Cai, Lu
Bai, Yang
Cui, Wenpeng
Luo, Ping
Miao, Li-ning
Tan, Yi
Miao, Xiao
Chen, Qiang
Rane, Madhavi J.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The present study was to investigate whether sulforaphane (SFN) can prevent diabetic nephropathy in type 1 diabetic mouse model induced by multiple low-dose streptozotocin.
Diabetic and age-matched control mice were given SFN at 0.5 mg/kg body weight daily for 3 months.
At the end of 3-month SFN treatment, the diabetic nephropathy, shown by renal inflammation, oxidative damage, fibrosis, and dysfunction, was significantly prevented along with an elevation of renal Nrf2 expression and transcription in diabetes/SFN group compared with diabetic group.
However, this renal prevention by SFN was not seen when the 3-month SFN-treated diabetic mice were aged for additional 3 months without further SFN treatment.
Nrf2-mediated renal protective effects in diabetes were evaluated in human renal tubular HK11 cells transfected with control and Nrf2 siRNA and treated with 27.5 mM mannitol or high glucose plus palmitate (300 μM).
Blockade of Nrf2 expression completely abolished SFN prevention of the profibrotic effect induced by high glucose plus palmitate.
These results support that renal Nrf2 expression and its transcription play important roles in SFN prevention of diabetes-induced renal damage.
However, the SFN preventive effect on diabetes-induced renal pathogeneses is not sustained, suggesting the requirement of continual use of SFN for its sustained effect.
American Psychological Association (APA)
Cui, Wenpeng& Bai, Yang& Miao, Xiao& Luo, Ping& Chen, Qiang& Tan, Yi…[et al.]. 2012. Prevention of Diabetic Nephropathy by Sulforaphane : Possible Role of Nrf2 Upregulation and Activation. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-500893
Modern Language Association (MLA)
Cui, Wenpeng…[et al.]. Prevention of Diabetic Nephropathy by Sulforaphane : Possible Role of Nrf2 Upregulation and Activation. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-500893
American Medical Association (AMA)
Cui, Wenpeng& Bai, Yang& Miao, Xiao& Luo, Ping& Chen, Qiang& Tan, Yi…[et al.]. Prevention of Diabetic Nephropathy by Sulforaphane : Possible Role of Nrf2 Upregulation and Activation. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-500893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500893