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Male Central Precocious Puberty : Serum Profile of Anti-Müllerian Hormone and Inhibin B before, during, and after Treatment with GnRH Analogue
Joint Authors
Andreone, Luz
Bedecarrás, Patricia
Ropelato, María Gabriela
Rey, Rodolfo A.
Grinspon, Romina P.
Campo, Stella M.
Bergadá, Ignacio
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We aimed to describe the functional changes of Sertoli cells, based on the measurement of serum anti-Müllerian hormone (AMH) and inhibin B during treatment with GnRHa and after its withdrawal in boys with central precocious puberty.
Six boys aged 0.8 to 5.5 yr were included.
AMH was low at diagnosis in patients >1 yr but within the normal range in younger patients.
AMH increased to normal prepubertal levels during treatment.
After GnRHa withdrawal, AMH declined concomitantly with the rise in serum testosterone.
At diagnosis, inhibin B was elevated and decreased throughout therapy, remaining in the upper normal prepubertal range.
In patients with testicular volume above 4 mL AMH remained higher in spite of suppressed FSH.
After treatment withdrawal, inhibin B rose towards normal pubertal levels.
In conclusion, AMH did not decrease in patients <1 yr reflecting the lack of androgen receptor expression in Sertoli cells in early infancy.
Serum inhibin B might result from the contribution of two sources: the mass of Sertoli cells and the stimulation exerted by FSH.
Sertoli cell markers might provide additional tools for the diagnosis and treatment followup of boys with central precocious puberty.
American Psychological Association (APA)
Grinspon, Romina P.& Andreone, Luz& Bedecarrás, Patricia& Ropelato, María Gabriela& Rey, Rodolfo A.& Campo, Stella M.…[et al.]. 2013. Male Central Precocious Puberty : Serum Profile of Anti-Müllerian Hormone and Inhibin B before, during, and after Treatment with GnRH Analogue. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-500914
Modern Language Association (MLA)
Grinspon, Romina P.…[et al.]. Male Central Precocious Puberty : Serum Profile of Anti-Müllerian Hormone and Inhibin B before, during, and after Treatment with GnRH Analogue. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-500914
American Medical Association (AMA)
Grinspon, Romina P.& Andreone, Luz& Bedecarrás, Patricia& Ropelato, María Gabriela& Rey, Rodolfo A.& Campo, Stella M.…[et al.]. Male Central Precocious Puberty : Serum Profile of Anti-Müllerian Hormone and Inhibin B before, during, and after Treatment with GnRH Analogue. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-500914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500914