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Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus : The Old and the New
Joint Authors
Ronchetti, Simona
Riccardi, Carlo
Nocentini, Giuseppe
Bartoloni, Elena
Gerli, Roberto
Caterbi, Sara
Alunno, Alessia
Valentini, Valentina
Bistoni, Onelia
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Pathogenic mechanisms underlying the development of systemic lupus erythematosus (SLE) are very complex and not yet entirely clarified.
However, the pivotal role of T lymphocytes in the induction and perpetuation of aberrant immune response is well established.
Among T cells, IL-17 producing T helper (Th17) cells and regulatory T (Treg) cells represent an intriguing issue to be addressed in SLE pathogenesis, since an imbalance between the two subsets has been observed in the course of the disease.
Treg cells appear to be impaired and therefore unable to counteract autoreactive T lymphocytes.
Conversely, Th17 cells accumulate in target organs contributing to local IL-17 production and eventually tissue damage.
In this setting, targeting Treg/Th17 balance for therapeutic purposes may represent an intriguing and useful tool for SLE treatment in the next future.
In this paper, the current knowledge about Treg and Th17 cells interplay in SLE will be discussed.
American Psychological Association (APA)
Alunno, Alessia& Bartoloni, Elena& Bistoni, Onelia& Nocentini, Giuseppe& Ronchetti, Simona& Caterbi, Sara…[et al.]. 2012. Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus : The Old and the New. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-500916
Modern Language Association (MLA)
Alunno, Alessia…[et al.]. Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus : The Old and the New. Clinical and Developmental Immunology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-500916
American Medical Association (AMA)
Alunno, Alessia& Bartoloni, Elena& Bistoni, Onelia& Nocentini, Giuseppe& Ronchetti, Simona& Caterbi, Sara…[et al.]. Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus : The Old and the New. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-500916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500916