Metabolomic Strategy for Studying the Intervention and the Synergistic Effects of the Shexiang Baoxin Pill for Treating Myocardial Infarction in Rats
Joint Authors
Liu, Xiaojun
Zhang, Weidong
Yue, Rongcai
Liu, Runhui
Jiang, Peng
Hu, Yaohua
Xiang, Li
Wang, Shuping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A metabolomic approach has been developed for evaluating the therapeutic effects of the bioactive components and the synergistic efficacy of the Shexiang Baoxin Pill (SBP) on myocardial infarction (MI) in rats.
The MI rats were administered the SBP, muscone, cinnamic acid, bufalin, ginsenoside Re, ginsenoside Rb1, cholic acid, borneol, and a combined version of these bioactive components (SFSBP).
Liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS) was used to obtain the mass data from the rats’ serum.
The number of biomarkers that were reversed by SFSBP was greater than any of the monotherapy groups.
The PLS-DA score plots demonstrated that the SFSBP group results were located closer to the sham group than any of the monotherapy groups and that the SBP group was located closer to the sham group than the SFSBP treatment group.
The reversing results observed with SFSBP showed synergistic effects when compared with those of the individual bioactive components that were used as monotherapy.
Meanwhile, the SBP displayed superior regulation efficacy to SFSBP in MI rats, indicating that there must be other active components in the SBP that were responsible for the treatment of MI that were not included in the SFSBP treatment.
American Psychological Association (APA)
Xiang, Li& Jiang, Peng& Wang, Shuping& Hu, Yaohua& Liu, Xiaojun& Yue, Rongcai…[et al.]. 2013. Metabolomic Strategy for Studying the Intervention and the Synergistic Effects of the Shexiang Baoxin Pill for Treating Myocardial Infarction in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-500921
Modern Language Association (MLA)
Xiang, Li…[et al.]. Metabolomic Strategy for Studying the Intervention and the Synergistic Effects of the Shexiang Baoxin Pill for Treating Myocardial Infarction in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-500921
American Medical Association (AMA)
Xiang, Li& Jiang, Peng& Wang, Shuping& Hu, Yaohua& Liu, Xiaojun& Yue, Rongcai…[et al.]. Metabolomic Strategy for Studying the Intervention and the Synergistic Effects of the Shexiang Baoxin Pill for Treating Myocardial Infarction in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-500921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500921