![](/images/graphics-bg.png)
Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue
Joint Authors
Froguel, Philippe
Frühbeck, Gema
Pattou, François
Poulain-Godefroy, Odile
Le Bacquer, Olivier
Lecœur, Cécile
Plancq, Pauline
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
It was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity.
Here, we question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obese adipose tissue.
We thus studied the expression of TLR1, TLR2, TLR4, and TLR6 in adipose tissue.
These receptors are expressed in omental and subcutaneous human fat tissue, the expression being higher in the omental tissue, independently of the metabolic status of the subject.
We demonstrated a correlation of TLRs expression within and between each depot suggesting a coregulation.
Murine 3T3-L1 preadipocyte cells stimulated with Pam3CSK4 induced the expression of some proinflammatory markers.
Therefore, beside TLR4, other toll-like receptors are differentially expressed in human fat tissue, and functional in an adipocyte cell line, suggesting that they might participate omental adipose tissue-related inflammation that occurs in obesity.
American Psychological Association (APA)
Poulain-Godefroy, Odile& Le Bacquer, Olivier& Plancq, Pauline& Lecœur, Cécile& Pattou, François& Frühbeck, Gema…[et al.]. 2010. Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-500951
Modern Language Association (MLA)
Poulain-Godefroy, Odile…[et al.]. Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue. Mediators of Inflammation No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-500951
American Medical Association (AMA)
Poulain-Godefroy, Odile& Le Bacquer, Olivier& Plancq, Pauline& Lecœur, Cécile& Pattou, François& Frühbeck, Gema…[et al.]. Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-500951
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500951