Regulation of Cerebral Blood Flow
Joint Authors
Wang, Zhengfeng
Britz, Gavin W.
Peterson, Eric C.
Source
International Journal of Vascular Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The control of cerebral blood flow is complex, and only beginning to be elucidated.
Studies have identified three key regulatory paradigms.
The first is cerebral pressure autoregulation, which maintains a constant flow in the face of changing cerebral perfusion pressure.
Flow-metabolism coupling refers to the brains ability to vary blood flow to match metabolic activity.
An extensive arborization of perivascular nerves also serves to modulate cerebral blood flow, so-called neurogenic regulation.
Central to these three paradigms are two cell types: endothelium and astrocytes.
The endothelium produces several vasoactive factors that are germane to the regulation of cerebral blood flow: nitric oxide, endothelium-dependent hyperpolarization factor, the eicosanoids, and the endothelins.
Astrocytic foot processes directly abut the blood vessels, and play a key role in regulation of cerebral blood flow.
Lastly, new research has been investigating cell-cell communication at the microvascular level.
Several lines of evidence point to the ability of the larger proximal vessels to coordinate vasomotor responses downstream.
American Psychological Association (APA)
Peterson, Eric C.& Wang, Zhengfeng& Britz, Gavin W.. 2011. Regulation of Cerebral Blood Flow. International Journal of Vascular Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-500959
Modern Language Association (MLA)
Peterson, Eric C.…[et al.]. Regulation of Cerebral Blood Flow. International Journal of Vascular Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-500959
American Medical Association (AMA)
Peterson, Eric C.& Wang, Zhengfeng& Britz, Gavin W.. Regulation of Cerebral Blood Flow. International Journal of Vascular Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-500959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500959