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H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma
Joint Authors
Medrano, Estela E.
Richards, Hunter W.
Lin, Qiushi
Curry, Jonathan L.
Martinez, Danielle R.
Torres-Cabala, Carlos A.
Prieto, Victor G.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The current study characterizes the mitosis-associated histone dual modification on the core of histone H3: trimethylation of histone H3 lysine 79 and simultaneous phosphorylation of H3 threonine 80 (H3K79me3T80ph).
Through the use of protein and microscopy-based techniques, we find that H3K79me3T80ph shares a similar spatial and temporal regulation as H3S10ph but additionally requires methyltransferase activity.
In addition, we find that Aurora kinase activity is necessary for the catalysis of H3K79me3T80ph in vivo.
Finally, our analysis of H3K79me3T80ph using a tissue microarray indicates that H3K79me3T80ph marks a subset of primary cutaneous melanomas with metastatic potential indicating that H3K79me3T80ph may identify a subset of invasive melanomas with a more aggressive clinical behaviour.
American Psychological Association (APA)
Martinez, Danielle R.& Richards, Hunter W.& Lin, Qiushi& Torres-Cabala, Carlos A.& Prieto, Victor G.& Curry, Jonathan L.…[et al.]. 2012. H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma. Journal of Skin Cancer،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-500962
Modern Language Association (MLA)
Martinez, Danielle R.…[et al.]. H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma. Journal of Skin Cancer No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-500962
American Medical Association (AMA)
Martinez, Danielle R.& Richards, Hunter W.& Lin, Qiushi& Torres-Cabala, Carlos A.& Prieto, Victor G.& Curry, Jonathan L.…[et al.]. H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma. Journal of Skin Cancer. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-500962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500962