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Combination Therapy of Sophoraflavanone B against MRSA : In Vitro Synergy Testing
Joint Authors
Lee, Young-Seob
Kim, Sung-Bae
Han, Sin-Hee
Seo, Yun-Soo
Joung, Dae-Ki
Ahn, Young-Sup
Kang, Ok-Hwa
Mun, Su-Hyun
Choi, Jang-Gi
Cha, Seon-Woo
Kwon, Dong-Yeul
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Sophoraflavanone B (SPF-B), a known prenylated flavonoid, was isolated from the roots of Desmodium caudatum.
The aim of this study was to determine the antimicrobial synergism of SPF-B combined with antibiotics against methicillin-resistant Staphylococcus aureus (MRSA).
MRSA, a multidrug-resistant pathogen, causes both hospital- and community-acquired infections worldwide.
The antimicrobial activity of SPF-B was assessed by the broth microdilution method, checkerboard dilution test, and time-kill curve assay.
The MIC of SPF-B for 7 strains of S.
aureus ranges from 15.6 to 31.25 μg/mL determined.
In the checkerboard method, the combinations of SPF-B with antibiotics had a synergistic effect; SPF-B markedly reduced the MICs of the β-lactam antibiotics: ampicillin (AMP) and oxacillin (OXI); aminoglycosides gentamicin (GET); quinolones ciprofloxacin (CIP) and norfloxacin (NOR) against MRSA.
The time-kill curves assay showed that a combined SPF-B and selected antibiotics treatment reduced the bacterial counts below the lowest detectable limit after 24 h.
These data suggest that the antibacterial activity of SPF-B against MRSA can be effectively increased through its combination with three groups of antibiotics (β-lactams, aminoglycosides, and quinolones).
Our research can be a valuable and significant source for the development of a new antibacterial drug with low MRSA resistance.
American Psychological Association (APA)
Mun, Su-Hyun& Kang, Ok-Hwa& Joung, Dae-Ki& Kim, Sung-Bae& Seo, Yun-Soo& Kwon, Dong-Yeul…[et al.]. 2013. Combination Therapy of Sophoraflavanone B against MRSA : In Vitro Synergy Testing. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-500986
Modern Language Association (MLA)
Kwon, Dong-Yeul…[et al.]. Combination Therapy of Sophoraflavanone B against MRSA : In Vitro Synergy Testing. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-500986
American Medical Association (AMA)
Mun, Su-Hyun& Kang, Ok-Hwa& Joung, Dae-Ki& Kim, Sung-Bae& Seo, Yun-Soo& Kwon, Dong-Yeul…[et al.]. Combination Therapy of Sophoraflavanone B against MRSA : In Vitro Synergy Testing. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-500986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-500986