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Detection of Herplex Simplex Virus-1 and -2 in Cardiac Myxomas
Joint Authors
Sakellariou, Stratigoula
Gorgoulis, Vassilis G.
Evangelou, Konstantinos
Liontos, Michalis
Kotsinas, Athanassios
Karakitsos, Petros
Pateras, Ioannis S.
Tsimaratou, Katerina
Papalois, Apostolos E.
Barlogiannis, Theodoros
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The etiology of sporadic cardiac myxomas remains elusive.
The tendency for these lesions to recur following resection, their immunopathological characteristics, along with their histological and molecular profile, may implicate the presence of an infective agent in this type of tumor.
In this study, we investigated the presence of herpes simplex virus (HSV) DNA in a cohort of cardiac myxomas in a tertiary referral centre.
Twenty-nine formalin-fixed paraffin-embedded (FFPE) sporadic cardiac myxomas were obtained, 17 of which were shown to be informative.
These were compared to 19 macroscopically and microscopically normal heart tissue specimens.
The detection of HSV-1 and -2 genomic sequences was achieved with the use of a combined nested PCR-Restriction Fragment Length Polymorphism methodology.
The presence of HSV-1 and/or -2 DNA was demonstrated in 6 of 17 (35%) informative sporadic cardiac myxomas, whereas no HSV DNA was detected in normal heart tissues (P<0.01).
The existence of HSV-1/2 DNA in sporadic cardiac myxomas, along with its absence from normal heart tissues, reinforces the possibility that HSV infection might be involved in the development of these lesions.
Our findings raise the point of anti-HSV medication postsurgically with a potential benefit in reducing the rate of recurrences.
American Psychological Association (APA)
Pateras, Ioannis S.& Evangelou, Konstantinos& Tsimaratou, Katerina& Liontos, Michalis& Sakellariou, Stratigoula& Barlogiannis, Theodoros…[et al.]. 2012. Detection of Herplex Simplex Virus-1 and -2 in Cardiac Myxomas. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-501011
Modern Language Association (MLA)
Pateras, Ioannis S.…[et al.]. Detection of Herplex Simplex Virus-1 and -2 in Cardiac Myxomas. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-501011
American Medical Association (AMA)
Pateras, Ioannis S.& Evangelou, Konstantinos& Tsimaratou, Katerina& Liontos, Michalis& Sakellariou, Stratigoula& Barlogiannis, Theodoros…[et al.]. Detection of Herplex Simplex Virus-1 and -2 in Cardiac Myxomas. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-501011
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501011