Protein Markers for the Differential Diagnosis of Vascular Dementia and Alzheimer’s Disease
Joint Authors
McGuire, J.
Simonsen, A. H.
Nilsson, T. K.
Waldemar, G.
Hagnelius, N.-O.
Source
International Journal of Proteomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Alzheimer’s disease (AD) is the most common form of dementia found in all human populations worldwide, while vascular dementia (VaD) is the second most common form of dementia.
New biomarkers for early and specific diagnosis of AD and VaD are needed to achieve greater insight into changes occurring in the brain and direct therapeutic strategies.
The objective of this explorative study was to discover candidate protein biomarkers for the differential diagnosis between VaD and AD.
Surface-enhanced laser desorption/ionization (SELDI) TOF-MS was used to differentially profile proteins and peptides in CSF samples from 28 AD patients and 21 patients with VaD.
A combination of univariate (Kruskal-Wallis) and multivariate (independent component analysis) statistical approaches produced a list of 27 proteins and peptides that could differentiate between VaD and AD.
These markers represent various physiological processes, such as protein degradation (ubiquitin), protease inhibition (cystatin C and alpha-1-antichymoptrypsin), and inflammation (C3a and C4a) that are known to be represented in neurodegenerative diseases.
American Psychological Association (APA)
Simonsen, A. H.& Hagnelius, N.-O.& Waldemar, G.& Nilsson, T. K.& McGuire, J.. 2012. Protein Markers for the Differential Diagnosis of Vascular Dementia and Alzheimer’s Disease. International Journal of Proteomics،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-501017
Modern Language Association (MLA)
Simonsen, A. H.…[et al.]. Protein Markers for the Differential Diagnosis of Vascular Dementia and Alzheimer’s Disease. International Journal of Proteomics No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-501017
American Medical Association (AMA)
Simonsen, A. H.& Hagnelius, N.-O.& Waldemar, G.& Nilsson, T. K.& McGuire, J.. Protein Markers for the Differential Diagnosis of Vascular Dementia and Alzheimer’s Disease. International Journal of Proteomics. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-501017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501017