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Administration of Glucosylceramide Ameliorated the Memory Impairment in Aged Mice
Joint Authors
Oh, Seikwan
Oliynyk, Sergiy
Lee, Yeonju
Han, Jeong Jun
Jung, Jae-Chul
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The function and the role of glucosylceramide have not been well studied in the central nervous system.
This study was aimed to investigate the possible roles of glucosylceramide in memory function in aged mice.
Glucosylceramide (50 mg/kg, p.o.) showed memory enhancing activity after 3-month treatment in the aged mice (C56BL/6, 18–20 months old) through Y-maze, novel objective test, and Morris water maze test.
Long-term treatment of glucosylceramide decreased the expression of iNOS and COX-2 in the brain of aged mice.
The LPS-induced mRNA level of iNOS, COX-2, IL-1β, and TNF-α was reduced by the acute treatment with glucosylceramide in adult mice.
These results suggest that glucosylceramide plays an important role in anti-inflammatory and memory enhancement, and it could be a potential new therapeutic agent for the treatment of neurodegenerative diseases such as Alzheimer’s disease.
American Psychological Association (APA)
Lee, Yeonju& Oliynyk, Sergiy& Jung, Jae-Chul& Han, Jeong Jun& Oh, Seikwan. 2013. Administration of Glucosylceramide Ameliorated the Memory Impairment in Aged Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-501029
Modern Language Association (MLA)
Lee, Yeonju…[et al.]. Administration of Glucosylceramide Ameliorated the Memory Impairment in Aged Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-501029
American Medical Association (AMA)
Lee, Yeonju& Oliynyk, Sergiy& Jung, Jae-Chul& Han, Jeong Jun& Oh, Seikwan. Administration of Glucosylceramide Ameliorated the Memory Impairment in Aged Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-501029
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501029