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Digging Up the Human Genome : Current Progress in Deciphering Adverse Drug Reactions
Joint Authors
Chung, Wen-Hung
Su, Shih-Chi
Hung, Shuen-Iu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Adverse drug reactions (ADRs) are a major clinical problem.
In addition to their clinical impact on human health, there is an enormous cost associated with ADRs in health care and pharmaceutical industry.
Increasing studies revealed that genetic variants can determine the susceptibility of individuals to ADRs.
The development of modern genomic technologies has led to a tremendous advancement of improving the drug safety and efficacy and minimizing the ADRs.
This review will discuss the pharmacogenomic techniques used to unveil the determinants of ADRs and summarize the current progresses concerning the identification of biomarkers for ADRs, with a focus on genetic variants for genes encoding drug-metabolizing enzymes, drug-transporter proteins, and human leukocyte antigen (HLA).
The knowledge gained from these cutting-edge findings will form the basis for better prediction and management for ADRs, ultimately making the medicine personalized.
American Psychological Association (APA)
Su, Shih-Chi& Chung, Wen-Hung& Hung, Shuen-Iu. 2014. Digging Up the Human Genome : Current Progress in Deciphering Adverse Drug Reactions. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-501051
Modern Language Association (MLA)
Su, Shih-Chi…[et al.]. Digging Up the Human Genome : Current Progress in Deciphering Adverse Drug Reactions. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-501051
American Medical Association (AMA)
Su, Shih-Chi& Chung, Wen-Hung& Hung, Shuen-Iu. Digging Up the Human Genome : Current Progress in Deciphering Adverse Drug Reactions. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-501051
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501051