Progress in the Identification of Dengue Virus EntryFusion Inhibitors
Joint Authors
De La Guardia, Carolina
Lleonart, Ricardo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Dengue fever, a reemerging disease, is putting nearly 2.5 billion people at risk worldwide.
The number of infections and the geographic extension of dengue fever infection have increased in the past decade.
The disease is caused by the dengue virus, a flavivirus that uses mosquitos Aedes sp.
as vectors.
The disease has several clinical manifestations, from the mild cold-like illness to the more serious hemorrhagic dengue fever and dengue shock syndrome.
Currently, there is no approved drug for the treatment of dengue disease or an effective vaccine to fight the virus.
Therefore, the search for antivirals against dengue virus is an active field of research.
As new possible receptors and biological pathways of the virus biology are discovered, new strategies are being undertaken to identify possible antiviral molecules.
Several groups of researchers have targeted the initial step in the infection as a potential approach to interfere with the virus.
The viral entry process is mediated by viral proteins and cellular receptor molecules that end up in the endocytosis of the virion, the fusion of both membranes, and the release of viral RNA in the cytoplasm.
This review provides an overview of the targets and progress that has been made in the quest for dengue virus entry inhibitors.
American Psychological Association (APA)
De La Guardia, Carolina& Lleonart, Ricardo. 2014. Progress in the Identification of Dengue Virus EntryFusion Inhibitors. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-501109
Modern Language Association (MLA)
De La Guardia, Carolina& Lleonart, Ricardo. Progress in the Identification of Dengue Virus EntryFusion Inhibitors. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-501109
American Medical Association (AMA)
De La Guardia, Carolina& Lleonart, Ricardo. Progress in the Identification of Dengue Virus EntryFusion Inhibitors. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-501109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501109