Therapeutic Potential of Autologous Stem Cell Transplantation for Cerebral Palsy
Joint Authors
Shitole, D. G.
Joshi, Meghnad
Kedari, Aarti
Bora, Neeta
Purandare, Chaitanya
Belle, Vaijayantee
Source
Case Reports in Transplantation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Cerebral palsy (CP) is a severe disabling disease with worldwide incidence being 2 to 3 per 1000 live births.
CP was considered as a noncurable, nonreparative disorder, but stem cell therapy offers a potential treatment for CP.
Objective.
The present study evaluates the safety and efficacy of autologous bone-marrow-derived mononuclear cell (BMMNCs) transplantation in CP patient.
Material and Methods.
In the present study, five infusions of autologous stem cells were injected intrathecally.
Changes in neurological deficits and improvements in function were assessed using Gross Motor Function Classification System (GMFCS-E&R) scale.
Results.
Significant motor, sensory, cognitive, and speech improvements were observed.
Bowel and bladder control has been achieved.
On the GMFCS-E&R level, the patient was promoted from grade III to I.
Conclusion.
In this study, we report that intrathecal infusion of autologous BMMNCs seems to be feasible, effective, and safe with encouraging functional outcome improvements in CP patient.
American Psychological Association (APA)
Purandare, Chaitanya& Shitole, D. G.& Belle, Vaijayantee& Kedari, Aarti& Bora, Neeta& Joshi, Meghnad. 2012. Therapeutic Potential of Autologous Stem Cell Transplantation for Cerebral Palsy. Case Reports in Transplantation،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-501131
Modern Language Association (MLA)
Purandare, Chaitanya…[et al.]. Therapeutic Potential of Autologous Stem Cell Transplantation for Cerebral Palsy. Case Reports in Transplantation No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-501131
American Medical Association (AMA)
Purandare, Chaitanya& Shitole, D. G.& Belle, Vaijayantee& Kedari, Aarti& Bora, Neeta& Joshi, Meghnad. Therapeutic Potential of Autologous Stem Cell Transplantation for Cerebral Palsy. Case Reports in Transplantation. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-501131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501131