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Antihyperlipidemic Potential of Polyphenol and Glycoside Rich Nerium oleander Flower against Triton WR-1339-Induced Hyperlipidemia in Experimental Sprague Dawley Rats
Joint Authors
Gayathri, V.
Vasanthi, Hannah R.
Ananthi, S.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nerium oleander Linn.
(NO), an evergreen cardiac glycoside-rich shrub is used as folklore medicine in China to treat many diseases.
It exhibits a wide spectrum of bioactivities but there were not much scientific reports on the bioactivity of N.
oleander flowers.
In the present study, we have evaluated the toxicity profile of the 50% hydroethanolic extracts of Nerium oleander flowers (ENO) using in vitro brine shrimp lethality assay and MTT cytotoxicity assay and in vivo acute toxicity test as per the OECD guidelines.
The antihyperlipidemic activity of the ENO was also studied using Triton WR-1339-induced hyperlipemic rats and compared with standard Atorvastatin.
In vitro brine shrimp, MTT cytotoxic assay, and in vivo acute toxicity assays showed a wide safety margin which has been evidenced through its lethal concentration (LC50: 795.46 μg/mL) and growth inhibition (GI50: 993.60 μg/ml) values.
Plasma lipids and lipoproteins were significantly elevated by the intraperitoneal injection of Triton WR 1339 in hyperlipidemic rats at 6th and 24th hour.
ENO pretreatment showed a significant ameliorative action on elevated lipids and lipoproteins in a dose-dependent manner when compared to standard.
Altogether, the results prove that Nerium oleander flowers are not toxic at the tested doses and exhibit antilipimic activity.
American Psychological Association (APA)
Gayathri, V.& Ananthi, S.& Vasanthi, Hannah R.. 2012. Antihyperlipidemic Potential of Polyphenol and Glycoside Rich Nerium oleander Flower against Triton WR-1339-Induced Hyperlipidemia in Experimental Sprague Dawley Rats. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-501132
Modern Language Association (MLA)
Gayathri, V.…[et al.]. Antihyperlipidemic Potential of Polyphenol and Glycoside Rich Nerium oleander Flower against Triton WR-1339-Induced Hyperlipidemia in Experimental Sprague Dawley Rats. Journal of Chemistry No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-501132
American Medical Association (AMA)
Gayathri, V.& Ananthi, S.& Vasanthi, Hannah R.. Antihyperlipidemic Potential of Polyphenol and Glycoside Rich Nerium oleander Flower against Triton WR-1339-Induced Hyperlipidemia in Experimental Sprague Dawley Rats. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-501132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501132