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Should Histologic Grade Be Incorporated into the TNM Classification System for Small (T1, T2) Node-Negative Breast Adenocarcinomas?
Joint Authors
Samayoa, Luis M.
Cibull, Michael L.
Karabakhtsian, Rouzan G.
Mcgrath, Patrick C.
Stratton, Terry D.
Purdom, Mathew
Romond, Edward H.
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Prognosis of invasive ductal carcinoma (IDC) strongly correlates with tumor grade as determined by Nottingham combined histologic grade.
While reporting grade as low grade/favorable (G1), intermediate grade/moderately favorable (G2), and high grade/unfavorable (G3) is recommended by American Joint Committee on Cancer (AJCC) staging system, existing TNM (Primary Tumor/Regional Lymph Nodes/Distant Metastasis) classification does not directly incorporate these data.
For large tumors (T3, T4), significance of histologic grade may be clinically moot as those are nearly always candidates for adjuvant therapy.
However, for small (T1, T2) node-negative (N0) tumors, grade may be clinically relevant in influencing treatment decisions, but data on outcomes are sparse and controversial.
This retrospective study analyzes clinical outcome in patients with small N0 IDC on the basis of tumor grade.
Our results suggest that the grade does not impact clinical outcome in T1N0 tumors.
In T2N0 tumors, however, it might be prognostically significant and relevant in influencing decisions regarding the need for additional adjuvant therapy and optimal management.
American Psychological Association (APA)
Purdom, Mathew& Cibull, Michael L.& Stratton, Terry D.& Samayoa, Luis M.& Romond, Edward H.& Mcgrath, Patrick C.…[et al.]. 2010. Should Histologic Grade Be Incorporated into the TNM Classification System for Small (T1, T2) Node-Negative Breast Adenocarcinomas?. Pathology Research International،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-501144
Modern Language Association (MLA)
Purdom, Mathew…[et al.]. Should Histologic Grade Be Incorporated into the TNM Classification System for Small (T1, T2) Node-Negative Breast Adenocarcinomas?. Pathology Research International No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-501144
American Medical Association (AMA)
Purdom, Mathew& Cibull, Michael L.& Stratton, Terry D.& Samayoa, Luis M.& Romond, Edward H.& Mcgrath, Patrick C.…[et al.]. Should Histologic Grade Be Incorporated into the TNM Classification System for Small (T1, T2) Node-Negative Breast Adenocarcinomas?. Pathology Research International. 2010. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-501144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501144