Modeling Presenilin-Dependent Familial Alzheimer's Disease : Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function
Joint Authors
Parent, Angèle T.
Thinakaran, Gopal
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mutations in PSEN genes, which encode presenilin proteins, cause familial early-onset Alzheimer's disease (AD).
Transgenic mouse models based on coexpression of familial AD-associated presenilin and amyloid precursor protein variants successfully mimic characteristic pathological features of AD, including plaque formation, synaptic dysfunction, and loss of memory.
Presenilins function as the catalytic subunit of γ-secretase, the enzyme that catalyzes intramembraneous proteolysis of amyloid precursor protein to release β-amyloid peptides.
Familial AD-associated mutations in presenilins alter the site of γ-secretase cleavage in a manner that increases the generation of longer and highly fibrillogenic β-amyloid peptides.
In addition to amyloid precursor protein, γ-secretase catalyzes intramembrane proteolysis of many other substrates known to be important for synaptic function.
This paper focuses on how various animal models have enabled us to elucidate the physiological importance of diverse γ-secretase substrates, including amyloid precursor protein and discusses their roles in the context of cellular signaling and synaptic function.
American Psychological Association (APA)
Parent, Angèle T.& Thinakaran, Gopal. 2010. Modeling Presenilin-Dependent Familial Alzheimer's Disease : Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-501169
Modern Language Association (MLA)
Parent, Angèle T.& Thinakaran, Gopal. Modeling Presenilin-Dependent Familial Alzheimer's Disease : Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-501169
American Medical Association (AMA)
Parent, Angèle T.& Thinakaran, Gopal. Modeling Presenilin-Dependent Familial Alzheimer's Disease : Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-501169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501169