Innate Pathways of Immune Activation in Transplantation
Joint Authors
Kuo, Paul C.
Brennan, Todd V.
Lunsford, Keri E.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Studies of the immune mechanisms of allograft rejection have predominantly focused on the adaptive immune system that includes T cells and B cells.
Recent investigations into the innate immune system, which recognizes foreign antigens through more evolutionarily primitive pathways, have demonstrated a critical role of the innate immune system in the regulation of the adaptive immune system.
Innate immunity has been extensively studied in its role as the host's first-line defense against microbial pathogens; however, it is becoming increasingly recognized for its ability to also recognize host-derived molecules that result from tissue damage.
The capacity of endogenous damage signals acting through the innate immune system to lower immune thresholds and promote immune recognition and rejection of transplant grafts is only beginning to be appreciated.
An improved understanding of these pathways may reveal novel therapeutic targets to decrease graft alloreactivity and increase graft longevity.
American Psychological Association (APA)
Brennan, Todd V.& Lunsford, Keri E.& Kuo, Paul C.. 2010. Innate Pathways of Immune Activation in Transplantation. Journal of Transplantation،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-501203
Modern Language Association (MLA)
Brennan, Todd V.…[et al.]. Innate Pathways of Immune Activation in Transplantation. Journal of Transplantation No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-501203
American Medical Association (AMA)
Brennan, Todd V.& Lunsford, Keri E.& Kuo, Paul C.. Innate Pathways of Immune Activation in Transplantation. Journal of Transplantation. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-501203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501203