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Relationship of Dietary Intake of Omega-3 and Omega-6 Fatty Acids with Risk of Prostate Cancer Development : A Meta-Analysis of Prospective Studies and Review of Literature
Joint Authors
Dy, Jun S.
Chua, Michael E.
Sio, Maria Christina D.
Sorongon-Legaspi, Mishell Kris
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
To determine the relationship between dietary omega-3 fatty acids (n-3 PUFA) and omega-6 fatty acids (n-6 PUFA) with prostate cancer risk from meta-analysis of prospective studies.
Design.
The literature retrieved from electronic biomedical databases up to June 2011 was critically appraised.
General variance-based method was used to pool the effect estimates at 95% confidence interval.
Heterogeneity was assessed by Chi2 and quantified by I2.
Results.
Eight cohort studies were included for meta-analysis.
n-3 PUFA, n-6 PUFA, and their derivatives were not significantly associated with risk of prostate cancer in general.
A significant negative association between high dietary intake of alpha-linolenic acid (ALA) and prostate cancer risk (pooled RR: 0.915; 95% CI: 0.849, 0.985; P=0.019) was noted.
Likewise, a slightly positive association was noted on dietary long-chain n-3 PUFA, composed of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with prostate cancer risk (pooled RR: 1.135; 95% CI: 1.008, 1.278; P=0.036); however, when two other cohort studies with data of EPA and DHA, both analyzed separately, were included into the pool, the association became not significant (RR: 1.034; 95% CI: 0.973, 1.096; P=0.2780).
Conclusion.
Intake of n-3 PUFA and n-6 PUFA does not significantly affect risk of prostate cancer.
High intake of ALA may reduce risk of prostate cancer, while intake of long-chain omega-3 fatty acids does not have a significant effect.
American Psychological Association (APA)
Chua, Michael E.& Sio, Maria Christina D.& Sorongon-Legaspi, Mishell Kris& Dy, Jun S.. 2012. Relationship of Dietary Intake of Omega-3 and Omega-6 Fatty Acids with Risk of Prostate Cancer Development : A Meta-Analysis of Prospective Studies and Review of Literature. Prostate Cancer،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-501206
Modern Language Association (MLA)
Chua, Michael E.…[et al.]. Relationship of Dietary Intake of Omega-3 and Omega-6 Fatty Acids with Risk of Prostate Cancer Development : A Meta-Analysis of Prospective Studies and Review of Literature. Prostate Cancer No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-501206
American Medical Association (AMA)
Chua, Michael E.& Sio, Maria Christina D.& Sorongon-Legaspi, Mishell Kris& Dy, Jun S.. Relationship of Dietary Intake of Omega-3 and Omega-6 Fatty Acids with Risk of Prostate Cancer Development : A Meta-Analysis of Prospective Studies and Review of Literature. Prostate Cancer. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-501206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501206