Synthesis of the Nakanishi Ring-Locked Retinoid
Joint Authors
Berman, Judd M.
Côté, Jamie B.
Garvey, David S.
Demenev, Andrey P.
Quach, Tan D.
Source
International Journal of Medicinal Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
An optimized synthetic route to prepare ring-locked retinoid 1a has been developed.
We fully describe a purification protocol that provides isomerically pure 1a in support of on-going proof of concept studies for the development of therapeutic agents to treat human ADRP.
Additionally, we have found that isomerically pure 1a can be stored in amber vials under argon at −20°C for use over time (up to six months) without degradation.
Thus, enabling 1a to be an accessible and valuable biological tool.
American Psychological Association (APA)
Côté, Jamie B.& Quach, Tan D.& Demenev, Andrey P.& Garvey, David S.& Berman, Judd M.. 2011. Synthesis of the Nakanishi Ring-Locked Retinoid. International Journal of Medicinal Chemistry،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-501258
Modern Language Association (MLA)
Côté, Jamie B.…[et al.]. Synthesis of the Nakanishi Ring-Locked Retinoid. International Journal of Medicinal Chemistry No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-501258
American Medical Association (AMA)
Côté, Jamie B.& Quach, Tan D.& Demenev, Andrey P.& Garvey, David S.& Berman, Judd M.. Synthesis of the Nakanishi Ring-Locked Retinoid. International Journal of Medicinal Chemistry. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-501258
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-501258